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Short-lived bioluminescence in cells
The Technology Bioluminescence is the production of light by a living organism. Cloning of the genes responsible for this bioluminescence has led to their use in many applications, ranging from environmental monitoring (glowing in response to a stimulus) to glowing fish production. One characteristic of this bioluminescence is that the Lux proteins...
Published: 6/10/2013   |   Updated: 6/10/2013   |   Inventor(s): Michael Allen, Rakesh Gupta, Gary Sayler
Keywords(s): Biologics and Assays, Drug Discovery
Category(s): Research Tools
8MDP-Fluorescein: A Novel Equilibrative Nucleoside Transporter Probe probe
Reference: PD 12021-05 The Technology Nucleoside transporters are integral membrane glycoproteins that play critical roles in physiological nucleoside and nucleobase fluxes, and influence the efficacy of many nucleoside chemotherapy drugs. Fluorescent reporter ligands/substrates have been shown to be useful in the analysis of nucleoside transporter...
Published: 5/21/2013   |   Updated: 5/21/2013   |   Inventor(s): John Buolamwini, Lin Wenwei
Keywords(s): Fluorescent probe, Nucleoside transporter, Research Tools and Reagents
Category(s): Research Tools, Human Health
A New Oxyma Derivative for Amide-forming Reactions in Water
Reference: PD 12110 Background In amide-forming reactions with R-amino acids, the use of a coupling additive such as benzotriazole derivatives (e.g., 1-hydroxy-7-azabenzotriazole (HOAt) and hydroxybenzotriazole (HOBt)) is essential to suppress racemization and improve the efficacy of peptide synthesis. Oxyma, ethyl 2-cyano-2-(hydroxyimino)acetate,...
Published: 6/4/2013   |   Updated: 5/21/2013   |   Inventor(s): Michio Kurosu, Qinghui Wang, Yong Wang
Keywords(s): Chemical reagent, Peptide synthesis, Peptides, Research Tools and Reagents
Category(s): Research Tools, Chemistry & Materials