Search Results - human+health

22 Results Sort By:
Primary cilium-polycystin complex, a novel mechanosensing pathway in bone
Reference: PD 12083The Problem The skeleton adapts to alterations in mechanical loading by changing bone structure. Increased load results in increased bone mass as a result of increased osteoblast-mediated bone formation , whereas skeletal unloading, which occurs with immobilization, disuse, and exposure to low gravity, leads to low bone mass from...
Published: 6/13/2013   |   Updated: 6/12/2013   |   Inventor(s): Zhousheng Xiao, L. Darryl Quarles
Keywords(s): Therapeutics
Category(s): Human Health
Interferon gene signature for clinical use
Reference: PD 10023  The Problem Interferon (IFN) therapy, the conventional treatment for Hepatitis C (Hep C), presents with several drawbacks. These drawbacks include a long treatment trial to determine patient response to IFN, inefficiency in a significant number of patients, and significant side effects.  The response rate to IFN therapy is approximately...
Published: 6/13/2013   |   Updated: 6/12/2013   |   Inventor(s): Lawrence Pfeffer, Meiyun Fan, Charles Handorf, Susan Pfeffer
Keywords(s): Diagnostics, Infectious Diseases
Category(s): Human Health
Two monoclonal antibodies that specifically inhibit plasminogen activated induced by TPA
Reference: PD 13059  The Problem Although tissue plasminogen activator (TPA) is an effective therapy for ischemic stroke, it also causes severe and fatal bleeding in some patients.  Fear of bleeding and the lack of a specific antidote has led to widespread underuse of TPA by physicians. Serious bleeding occurs in 7-9% of ischemic stroke patients treated...
Published: 6/13/2013   |   Updated: 6/12/2013   |   Inventor(s): Guy Reed
Keywords(s): Biologics, Cardiovascular, Therapeutics
Category(s): Human Health
The two step neutralizing mouth wash to minimize the effects of acid erosion on tooth enamel.
Reference: PD13045The Problem Dental erosion is a significant oral health problem. It is exacerbated by highly acidic diets, certain medications causing low salivary flow, and systemic conditions such as gastroesophogeal reflux (GERD), and bulimia. Erosive tooth wear from hydrochloric acid occurs when stomach juice is regurgitated in conditions such...
Published: 6/13/2013   |   Updated: 6/11/2013   |   Inventor(s): Mojdeh Dehghan, Daranee VersluiS-Tanbirojn
Keywords(s): Dental product
Category(s): Human Health
The use of asialo-galactosylated triantennary oligosaccharides and their derivatives to support photoreceptor outer segment membrane assembly
Reference: PD06050The Problem Age-related Macular Degeneration (AMD) affects millions of people, progressively robbing them of their central vision and significantly reducing their quality of life. Without central vision, they are unable to read, recognize faces, drive, or perform countless daily activities. The vast majority of AMD cases consist of...
Published: 6/13/2013   |   Updated: 6/11/2013   |   Inventor(s): Monica Jablonski
Keywords(s): Ophthalmology, Therapeutics
Category(s): Human Health
Nanoparticle intraocular drug delivery system
Reference: PD 11048 The Problem Age-related Macular Degeneration (AMD) affects millions of people, progressively robbing them of their central vision and significantly reducing their quality of life. Without central vision, they are unable to read, recognize faces, drive, or perform countless daily activities. The vast majority of AMD cases consist...
Published: 6/13/2013   |   Updated: 6/11/2013   |   Inventor(s): Monica Jablonski, Mallika Palamoor
Keywords(s): Drug Delivery
Category(s): Human Health
Smart sense-and-respond bandage for the detection and treatment of wound infections
The TechnologyResearchers at The University of Tennessee have developed a sense-and-respond bandage for autonomous, closed-loop detection, communication, and self-mitigation of wound pathogens. Using an integrated genomic, biomedical, and nanotechnological approach, the inventors have engineered a biochip biosensor that detects the presence of bacterial...
Published: 6/10/2013   |   Updated: 6/7/2013   |   Inventor(s): Steven Ripp, James Fleming, Gary Sayler
Keywords(s): Anti-bacterial, Bacteria, Biomedical Engineering, Drug Delivery
Category(s): Engineering, Human Health
EtpA is a Novel Antigen for a Vaccine Against Enterotoxigenic Escherichia coli
Technical Field: Vaccine: Infectious Diarrhea The Technology Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrheal disease that kills 500,000 children annually in the developing world and also is the principle cause of traveler’s diarrhea. Considerable effort has been expended toward development of a vaccine, but progress has been hindered...
Published: 6/11/2013   |   Updated: 6/5/2013   |   Inventor(s): James Fleckenstein
Keywords(s): Infectious Diseases, Pediatrics, Vaccines
Category(s): Human Health
The Spine Robot - An Advanced Motion and Load Testing Platform
The Technology: The spine implant sector is one of the fastest growing segments of the medical device industry. At current growth rates the total market for spine implants is expected to exceed $10 billion within five years. The lead products in this market are fusion devices and artificial disks, which act to correct or replace portions of the spine...
Published: 6/13/2013   |   Updated: 6/5/2013   |   Inventor(s): Brian Kelly, Denis Diangelo
Keywords(s): Biomedical Engineering, Devices, Orthopedics
Category(s): Human Health
Inhibition of tumor growth and glioma invasion by anti matrix metalloproteinases DNAzyme
The Technology: Glioma is an aggressive cancer with a median survival of less than 12 months from diagnosis. Because of their location in the brain, most gliomas can not be fully removed by surgical resection. Recognizing that traditional small molecule therapeutics have not provided effective treatments for glioma, and that matrix metalloproteinase...
Published: 6/13/2013   |   Updated: 6/4/2013   |   Inventor(s): Tayebeh Pourmatabbed, Hisashi Hasegawa, Chad Batson
Keywords(s): Cancer therapeutics, Oligonucleotides, Oncology
Category(s): Human Health
1 2 3