Search Results - michio+kurosu

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Discovery of Selective Menaquinone Biosynthesis Inhibitors against Mycobacterium tuberculosis
Reference: PD 12060 Therapeutic: Antibacterial Background Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB) and is responsible for nearly two million deaths annually. Moreover, the emergence of multidrug-resistant (MDR) strains of Mtb seriously threatens TB control and prevention efforts. M. tuberculosis is recognized to lie in a non-replicating...
Published: 6/4/2013   |   Updated: 5/21/2013   |   Inventor(s): Michio Kurosu, Joy Debnath, Shajila Siricilla
Keywords(s): Anti-bacterial, Bacteria, Small molecule, Therapeutics, Tuberculosis
Category(s): Human Health
A New Oxyma Derivative for Amide-forming Reactions in Water
Reference: PD 12110 Background In amide-forming reactions with R-amino acids, the use of a coupling additive such as benzotriazole derivatives (e.g., 1-hydroxy-7-azabenzotriazole (HOAt) and hydroxybenzotriazole (HOBt)) is essential to suppress racemization and improve the efficacy of peptide synthesis. Oxyma, ethyl 2-cyano-2-(hydroxyimino)acetate,...
Published: 6/4/2013   |   Updated: 5/21/2013   |   Inventor(s): Michio Kurosu, Qinghui Wang, Yong Wang
Keywords(s): Chemical reagent, Peptide synthesis, Peptides, Research Tools and Reagents
Category(s): Research Tools, Chemistry & Materials