Search Results - peptides

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Anti-inflammatory Peptides to Inhibit Inflammation and Cartilage Degradation
Technical Field: Therapeutic: Arthritis and Inflammation The Problem: Matrix metalloproteinases (MMPs) are enzymes that cause tissue destruction in chronic diseases such as arthritis, degenerative disc disease, and skin ulcers. Primary MMP inhibitors have not been clinically successful. The Technology Solution: Using their knowledge of the molecular...
Published: 6/13/2013   |   Updated: 6/4/2013   |   Inventor(s): Karen Hasty, Arnold Postlethwaite, Sivadasan Kanangat
Keywords(s): Arthritis, Autoimmune, Inflammation, Peptides
Category(s): Human Health
Method for preventing cell infection by enveloped viruses such as cytomegalovirus (CMV)
The TechnologyCytomegalovirus (CMV) is the most common viral infection in infants born in the United States (1 in 150 children). Infection in utero can lead to long term disabilities such as mental retardation and hearing loss. As CMV is a herpesvirus, it creates lifelong latent infections. CMV is common in adults, and in immunocompromised patients...
Published: 6/4/2013   |   Updated: 6/2/2013   |   Inventor(s): Jonathan Wall, Timothy Sparer, Stephen Kennel, Angela Williams, Emily Martin, Pranay Dogra
Keywords(s): Anti-viral drugs, Peptides
Category(s): Human Health
A Toll-like Receptor (TLR)/Interleukin 1 Receptor (IL-1R) Pathway-specific Protein Kinase D1 Inhibitor
Reference: PD 13047 Technical Field Novel targets: Inflammatory and autoimmune diseases ­ The Technology Toll-like receptor (TLR)/interleukin 1 receptor (IL-1R) signaling plays a critical pathogenic role in many forms of inflammatory and...
Published: 6/4/2013   |   Updated: 5/21/2013   |   Inventor(s): AE-Kyung Yi, JeounG-Eun Park
Keywords(s): Arthritis, Autoimmune, Inflammatory, Peptides, Protein Kinase D1, Therapeutics
Category(s): Human Health
A New Oxyma Derivative for Amide-forming Reactions in Water
Reference: PD 12110 Background In amide-forming reactions with R-amino acids, the use of a coupling additive such as benzotriazole derivatives (e.g., 1-hydroxy-7-azabenzotriazole (HOAt) and hydroxybenzotriazole (HOBt)) is essential to suppress racemization and improve the efficacy of peptide synthesis. Oxyma, ethyl 2-cyano-2-(hydroxyimino)acetate,...
Published: 6/4/2013   |   Updated: 5/21/2013   |   Inventor(s): Michio Kurosu, Qinghui Wang, Yong Wang
Keywords(s): Chemical reagent, Peptide synthesis, Peptides, Research Tools and Reagents
Category(s): Research Tools, Chemistry & Materials