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Small Molecule Inhibitors of Autotaxin
Reference: PD 11016 The Technology Autotaxin (ATX, NPP2) is a member of the nucleotide pyrophosphate phosphodiesterase enzyme family. ATX catalyzes the hydrolytic cleavage of lysophosphatidylcholine (LPC) that leads to the generation of the growth factor-like lipid mediator lysophosphatidic acid (LPA). ATX is highly upregulated in metastatic...
Published: 5/30/2013   |   Updated: 5/28/2013   |   Inventor(s): Duane Miller, Gabor Tigyi, Renuka Gupte, Renukadevi Patil
Keywords(s): Autotaxin, Cancer, Cancer therapeutics, Oncology, Small molecule
Category(s): Human Health