Search Results - cancer+therapeutics

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Inhibition of tumor growth and glioma invasion by anti matrix metalloproteinases DNAzyme
The Technology: Glioma is an aggressive cancer with a median survival of less than 12 months from diagnosis. Because of their location in the brain, most gliomas can not be fully removed by surgical resection. Recognizing that traditional small molecule therapeutics have not provided effective treatments for glioma, and that matrix metalloproteinase...
Published: 6/13/2013   |   Updated: 6/4/2013   |   Inventor(s): Tayebeh Pourmatabbed, Hisashi Hasegawa, Chad Batson
Keywords(s): Cancer therapeutics, Oligonucleotides, Oncology
Category(s): Human Health
Small Molecule Inhibitors of Autotaxin
Reference: PD 11016 The Technology Autotaxin (ATX, NPP2) is a member of the nucleotide pyrophosphate phosphodiesterase enzyme family. ATX catalyzes the hydrolytic cleavage of lysophosphatidylcholine (LPC) that leads to the generation of the growth factor-like lipid mediator lysophosphatidic acid (LPA). ATX is highly upregulated in metastatic...
Published: 5/30/2013   |   Updated: 5/28/2013   |   Inventor(s): Duane Miller, Gabor Tigyi, Renuka Gupte, Renukadevi Patil
Keywords(s): Autotaxin, Cancer, Cancer therapeutics, Oncology, Small molecule
Category(s): Human Health